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自1951年开始应用异菸肼治疗结核病以来,经临床观察,其毒性反应主要表现在神经系统方面,包括:头昏、失眠、肌肉震颤、排尿困难、便秘、口干、多梦、兴奋、欣快症、皮肤感觉麻木或异常、轻度性格改变及痉挛等。此外,也可能引起中毒性精神病。据作者所知,关于异菸胼中毒性精神病,国外已有30余例报告,国内仅1956年吴善氏及1957年叶馥荪氏等各报导1例,最近王念斌氏等报告3例。鉴于该病比较少见,近三年来文献报导逐渐增多,为了引起大家注意,达到早期预防的目的,故特报告4例(其中1例经胰岛素低血糖治疗),并结合国内外有关文献略加讨论。
Since isoniazid treatment of tuberculosis since 1951, its clinical toxicity has been mainly manifested in the nervous system, including: dizziness, insomnia, muscle tremors, dysuria, constipation, dry mouth, dreaminess, excitement, Hyperactivity, skin feel numb or abnormal, mild personality changes and spasms. In addition, it may cause toxic psychosis. According to the author’s knowledge, there are more than 30 foreign reports of isoniazid-induced psychosis in China. In China, only 1 case was reported in 1956, including Wu Shanshi and 1957 Ye Fu-sun and 3 cases were recently reported by Wang Nianbin. In view of the disease is relatively rare, the literature reported in the past three years gradually increased, in order to attract everyone’s attention and achieve the purpose of early prevention, so special report 4 cases (including 1 case of insulin hypoglycemia treatment), combined with relevant literature at home and abroad a little discussion .