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用血小板自动平衡聚集仪建立血小板活化因子的生物活性检测法.测定了20例急性肾炎(AGN)患儿血浆PAF和尿lyso-PAF的水平,同时测定血C_3的含量.结果表明,AGN急性期血浆PAF及尿lyso-PAF显著高于对照组;AGN恢复期血浆PAF及尿lyso-PAF显著高于对照组;AGN恢复期血浆PAF及尿lyso-PAF均降至正常;血C_3与血浆PAF、尿lyso-PAF均呈明显的负相关.提示AGN急性期血PAF、尿lyso-PAF水平的增高与补体的沉积、肾小球的免疫损伤密切相关;PAF在急性肾炎的发病机制中可能具有重要的作用.
PAF and urine lyso-PAF were measured in 20 children with acute nephritis (AGN), and the content of C_3 in blood was measured at the same time.The results showed that the acute phase of AGN Plasma PAF and urinary lyso-PAF were significantly higher than those in the control group; plasma PAF and urinary lyso-PAF in the recovery phase of AGN were significantly higher than those in the control group; plasma PAF and urine lyso-PAF in the recovery phase of AGN were both normal; Urine lyso-PAF showed a significant negative correlation, suggesting that acute AGN blood PAF, urinary lyso-PAF levels increased complement deposition, glomerular immune damage is closely related; PAF may play an important role in the pathogenesis of acute nephritis Role.