肾素—血管紧张素系统在循环和局部血管壁中激活,除增加血管收缩和系统血管阻力外,还促进内皮功能紊乱、平滑肌生长和增殖,并与动脉粥样硬化发展有密切关系。实验和新的研究结果表明,血管紧张素转换酶抑制剂具有继发性或可能是原发性防治冠脉粥样硬化和冠心病的作用。 The renin-angiotensin system is activated in the circulation and in the local vessel wall. In addition to increasing vasoconstriction and systemic vascular resistance, the renin-angiotensin system also promotes endothelial dysfunction, smooth muscle growth and proliferation, and is closely related to the development of atherosclerosis. Experiments and new findings show that angiotensin converting enzyme inhibitors have secondary or may be the primary prevention and treatment of coronary atherosclerosis and coronary heart disease.