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患者韩某,男,20岁。因出现听幻觉、自笑、动作古怪6mo,于1984年6月11日至24日住某精神病院,诊断为精神分裂症。因使用氟哌啶醇出现严重锥体外系症状而自动出院,来我院门诊部治疗。来诊时精神症状已消失,自知力恢复,但四肢肌张力增高、震颤、出现明显帕金森征。即改服硫利哒嗪(thioridazine)治疗,锥体外系症状逐渐消失,后因硫利哒嗪缺药,从1985年5月10日起改服氯氮平治疗,剂量为100mg/d,病情一直稳定。于1986年1月初开始出现口渴、多饮、多尿。1月28日起伴低热、大汗、头痛、腹胀、不停呃逆、便秘、烦躁不安等症状,即来诊,当时查体:血压18.6/13.3kPa(140/100mmHg)、体温37.8℃,心肺未见异常,神
Patient Hanmou, male, 20 years old. Because of the auditory hallucinations, self-laughing, eccentric movements 6mo, in June 11, 1984 to 24, a mental hospital, diagnosed as schizophrenia. Due to the use of haloperidol appears serious symptoms of extrapyramidal discharge, to our hospital clinic treatment. Visiting psychiatric symptoms have disappeared, aware of the power recovery, but limb muscle tension increased, tremor, obvious Parkinson’s sign. That is to change clothes thioridazine (thioridazine) treatment, extrapyramidal symptoms gradually disappear, after thiazide drug deficiency, from May 10, 1985 change service clozapine treatment, the dose of 100mg / d, the condition Has been stable. In early January 1986 began to thirst, polydipsia, polyuria. January 28 with low fever, sweating, headache, bloating, non-stop hiccups, constipation, restlessness and other symptoms, that is, the visit, was physical examination: blood pressure 18.6 / 13.3kPa (140 / 100mmHg), body temperature 37.8 ℃, No abnormalities, God