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目的探讨早期干预对中、重度新生儿缺血缺氧性脑病(HIE)预后的影响,降低HIE神经系统后遗症的发生率。方法将78例中、重度HIE患儿随机分为治疗组和对照组,其中治疗组48例,对照组30例。治疗组从新生儿期即进行早期干预,对照组给予常规治疗。结果比较两组2~3 d、14~16 d、26~28 d神经行为测试值,治疗组明显高于对照组(P<0.05);对两组患儿智能发育商数进行测评,治疗组智能发育商数明显高于对照组(P<0.05)。结论对HIE患儿进行早期干预,能降低中、重度HIE神经系统后遗症的发生,减少智能落后及伤残程度,提高患儿的生存质量。
Objective To investigate the effect of early intervention on the prognosis of moderate and severe neonatal hypoxic-ischemic encephalopathy (HIE) and to reduce the incidence of neurological sequelae in HIE. Methods 78 cases of moderate and severe HIE were randomly divided into treatment group and control group, of which 48 cases in the treatment group and 30 cases in the control group. The treatment group from the early neonatal intervention, the control group given conventional treatment. Results The neurobehavioral test values at 2 ~ 3 d, 14 ~ 16 d and 26 ~ 28 d were compared between the two groups and the treatment group was significantly higher than that of the control group (P <0.05). The intelligence quotient of two groups was evaluated. The number of intelligent development was significantly higher than that of the control group (P <0.05). Conclusion Early intervention in children with HIE can reduce the incidence of moderate and severe seizures of the HIE nervous system, reduce the level of intelligence lag and disability, and improve the quality of life in children.