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乙胺碘呋酮(胺碘酮、安律酮)是一种广谱而有效的抗心律失常药,它是含碘的苯丙呋喃衍生物。其合成史已20余年,开始是作为扩冠药物以治心绞痛,自1970年始用于抗心律失常,1974年Rosenbaum 等用其治疗预激综合征患病的室上性心动过速,取得了很好疗效。现人们已对它的电生理及药物动力学等有进一步的了解,国内外已将其广为应用于抗心律失常。一、药物动力学及电生理作用乙胺碘呋酮属于第3类抗心律失常药,是α和β肾上腺素能受体的非竞争性阻滞剂,其细胞电生理效应是:(1)延长心房、心室和浦倾野细胞的动
Amiodarone (amiodarone, antonone) is a broad-spectrum and potent anti-arrhythmic drug that is an iodine-containing benzofuran derivative. The synthesis history of more than 20 years, beginning as the crown of the drug to treat coronary heart disease, since the beginning of 1970 for anti-arrhythmia, 1974, Rosenbaum et al used to treat pre-excitation syndrome of supraventricular tachycardia, and achieved very Good effect. Now people have its electrophysiology and pharmacokinetics and so have a better understanding, both at home and abroad has been widely used in anti-arrhythmia. First, the pharmacokinetics and electrophysiological effects Amiodarone is a type 3 antiarrhythmic drug, α and β adrenergic receptor non-competitive blocker, the cell electrophysiological effects are: (1) Extend the atria, ventricle and Pu Tiao field cells move