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目的探讨木漆挥发物经呼吸道染毒对小鼠骨髓细胞和脾脏的损伤。方法将小鼠暴露于高、中、低不同浓度的底漆(320、600、900 mg/m3)和面漆(320、580、840 mg/m3)挥发物环境中,每组10只,每天2 h吸入染毒,持续4周后进行胸骨骨髓象和脾病理学检查。结果底漆和面漆染毒小鼠的骨髓象幼粒细胞、分叶细胞、幼红细胞、淋巴细胞和巨核细胞占有核细胞的百分率均随染毒剂量的增加而上升,各组间差异均有统计学意义(P<0.01)。染毒小鼠脾病理结果显示,在底漆和面漆高剂量组中均出现白髓比例增大、脾小结淋巴细胞增多和中央动脉淋巴鞘增厚。结论本实验浓度下木漆挥发物暴露对小鼠造血微环境产生影响,阻碍了幼稚细胞的分化成熟。
OBJECTIVE To investigate the damage of bone marrow cells and spleen in mice exposed to volatiles from wood varnish through the respiratory tract. Methods Mice were exposed to high, medium and low concentrations of primers (320, 600, 900 mg / m3) and topcoats (320, 580, 840 mg / m3) 2 h inhalation exposure, for 4 weeks after the sternal bone marrow and spleen pathological examination. Results The percentages of myeloid cells, myeloid cells, erythrocytes, lymphocytes and megakaryocytes possessing nuclear cells in the bone marrow of primed and topcoated mice all increased with the increase of the dose, and the differences among the groups were Statistical significance (P <0.01). The pathological results of spleens in mice showed that the proportion of white pulp increased, the number of splenic lymphocytes increased and the thickness of central artery lymph sheath increased in the high-primer and top-coat high-dose groups. Conclusion Exposure of volatile varnish to the hematopoietic microenvironment affects the differentiation and maturation of immature cells.