粘膜恶性黑素瘤（恶黑）除常发生于皮肤外，也可见于鼻腔、口腔、肛管等粘膜组织。由于其组织结构和细胞形态复杂多样，病理诊断有一定难度，光镜下以找到胞浆内黑素颗粒为诊断恶黑的可靠依据。但粘膜原发性恶黑有相当一部分光镜下缺乏黑素颗粒（即无色素性恶黑），可通过... In addition to mucosal malignant melanoma (bad black) often occurs in the skin, but also in the nasal cavity, oral cavity, anal canal and other mucosal tissue. Because of its complex structure and cell morphology, pathological diagnosis is difficult, and light microscopy to find cytoplasmic melanin granules is a reliable basis for the diagnosis of vicious black. However, a considerable part of the mucosal primary malignant black pigment lacks melanin granules (ie, non-pigmented vicious black), which can pass...