80年代以来,脑内烟碱受体受到极大重视,特别是电生理膜片钳技术和分子生物学的应用,大大推进了烟碱受体结构、功能和配体的研究。目前已克隆了神经元烟碱受体的α2-9和β2-4共11个亚基;烟碱受体离子通道的生物物理特性也得到阐明。研究表明,烟碱受体与学习记忆及老年痴呆的发病和吸烟成瘾等密切 Since the 1980s, nicotinic receptors in the brain have received great attention. In particular, electrophysiological patch clamp techniques and molecular biology have greatly promoted the studies on the structure, function and ligand of nicotine receptors. Up to now, 11 subunits α2-9 and β2-4 of nicotinic receptor have been cloned. The biophysical properties of nicotinic receptor ion channels have also been elucidated. Studies have shown that nicotinic receptors and learning and memory and Alzheimer’s disease and smoking addiction are closely related