论文部分内容阅读
目的 探讨感觉统合失调儿童血清儿茶酚胺递质水平与相关行为的关系。方法 采用放射免疫方法定量检测 40例感觉统合失调儿童 (研究组 )及 46名健康儿童 (对照组 )的血清肾上腺素(A)、去甲肾上腺素 (NE)、多巴胺 (DA)水平 ,并比较两组的注意力缺陷次数、智商 (IQ)、心率及学习困难出现率。结果 研究组的血清A为 (0 6 4± 0 19)nmol/L ,NE为 (3 2 0± 0 6 6 )nmol/L ,DA为 (1 45±0 2 0 )nmol/L ,均高于对照组 [分别为 (0 5 2± 0 10 )nmol/L、(2 2 3± 0 6 1)nmol/L、(1 31± 0 18)nmol/L],差异有非常显著性和显著性 (P <0 0 1和 0 0 5 )。研究组的注意力缺陷次数 [(8± 1)次 ]多于对照组[5± 2次 ;P <0 0 1],心率 [(83± 6 )次 ]快于对照组 [(78± 3)次 ];P <0 0 1) ,学习困难出现率 (42 % )高于对照组 (15 % ;P <0 0 1) ;IQ水平两组差异无显著性 (P >0 0 5 )。结论 感觉统合失调儿童血清A、NE及DA呈高水平失衡 ,并有与其相关的交感神经活动性行为表现。
Objective To explore the relationship between serum catecholamine neurotransmitters and related behaviors in children with sensory integration disorder. Methods The levels of serum adrenaline (A), norepinephrine (NE) and dopamine (DA) were measured by radioimmunoassay in 40 children with sensory integration disorder (study group) and 46 healthy children (control group) The number of attention deficits, IQ, heart rate and learning difficulties in both groups. Results Serum A was (0 6 4 ± 0 19) nmol / L in the study group, NE was (320 ± 0 6 6) nmol / L and DA was (1 45 ± 0 2 0) nmol / L, (0 52 ± 0 10 nmol / L, (2 2 3 ± 0 6 1) nmol / L, (1 31 ± 0 18) nmol / L, respectively] in the control group. There was a significant difference between the two groups (P <0 0 1 and 0 0 5). The number of attention deficits in the study group was significantly higher than that in the control group [(8 ± 1) times [(5 ± 2) times; P <0.01] and heart rate [(83 ± 6) ) Times]; P <0.01). The incidence of learning difficulties (42%) was higher than that of the control group (15%; P <0.01). There was no significant difference in IQ between the two groups (P> 0.05). Conclusions Serum A, NE and DA in children with sensory integration disorder show a high level of imbalance and have associated with it the behavior of sympathetic activity.