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用银染色法、免疫组织化学及透射电镜技术,对36例人肺的神经内分泌细胞进行了形态学和免疫组织化学观察。结果显示,生后肺的神经内分泌细胞(NE细胞)多位于肺内支气管上皮内,其数量在1周岁后迅速减少,并保持在最低水平。NE细胞多为封闭型,呈圆形。神经上皮小体(NEB)为团状,表面有上皮细胞与腔面相隔。5-HT阳性NE细胞和降钙素阳性NE细胞为锥形,很少形成NEB。NE细胞超微结构显示,胞质内细胞器丰富,并含具特征性的致密核芯小泡。根据生后肺的NE细胞数量变化、形态结构和免疫组织化学特征,提示NE细胞发生了废用性退化,其原因可能与出生前后人肺功能改变有关。
36 cases of human lung neuroendocrine cells were observed morphologically and immunohistochemically by silver staining, immunohistochemistry and transmission electron microscopy. The results showed that the number of neuroendocrine cells (NE cells) in the lungs were mainly located in the lung bronchial epithelium after birth, the number of which decreased rapidly after one year of age and kept at the lowest level. NE cells are mostly closed, round. Neuroepithelial bodies (NEBs) are clumps, with epithelial cells separated from the luminal surface. 5-HT-positive NE cells and calcitonin-positive NE cells are pyramidal and rarely form NEBs. The ultrastructure of NE cells showed abundant organelles in the cytoplasm and contained characteristic dense core vesicles. According to the changes of the number of NE cells, the morphological structure and the immunohistochemical characteristics of the postnatal lung, it is suggested that the degeneration of the NE cells degenerated, which may be related to the change of the lung function before and after birth.