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多发性骨髓瘤(multiple myeloma,MM)是浆细胞的恶性肿瘤。骨髓瘤细胞起源于B记忆细胞或幼浆细胞。细胞因子白介素-6(IL-6)是促进B细胞分化成浆细胞的调节因子。进展性MM患者骨髓中IL-6异常升高,提示以IL-6为中心的细胞因子网络失调导致骨髓瘤细胞增生。我国MM发病率约为1/10万,低于西方工业发达国家(约4/10万)。发病年龄大多在(50～60)岁之间,40岁以下者较少见,男女之比为3:2。近年来,随着我国人口老龄化,骨髓瘤的发病率正在
Multiple myeloma (MM) is a malignant tumor of plasma cells. Myeloma cells originate from B memory cells or meiotic cells. Cytokine Interleukin-6 (IL-6) is a regulatory factor that promotes the differentiation of B cells into plasma cells. Abnormal IL-6 levels in the bone marrow of patients with progressive MM suggest that IL-6-centered cytokine network dysregulation leads to proliferation of myeloma cells. The incidence of MM in China is about 1/10 million, which is lower than that of western industrialized countries (about 4 / 100,000). Most of the onset age (50 to 60) years of age, less than 40 years of age are less common, the ratio of men to women is 3: 2. In recent years, with the population aging in China, the incidence of myeloma is being