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本文综述洋地黄中毒反应的细胞电生理机制。洋地黄是用于研究心律失常细胞电生理机制的主要工具之一。历史性发展中毒浓度洋地黄能降低房室结、希-浦系、心房和心室肌细胞的静息电位和最大除极速率,降低各组织动作电位的幅度,使复极加快。窦房结纤维也加速复极。Vassalle 等报告,哇巴因对特殊传导纤维的作用较对心肌纤维为大。中毒主要表现为4相除极坡度增加,引起期外收缩和持续
This review summarizes the cellular electrophysiological mechanisms of digitalis poisoning. Digitalis is one of the major tools used to study electrophysiological mechanisms of arrhythmic cells. The historic development of poisoning concentration of digitalis can reduce atrioventricular node, Greek - Pu system, atrial and ventricular myocytes resting potential and maximum depolarization rate, reduce the magnitude of the action potential of each tissue, so that repolarization speed up. Sinus node fibers also accelerate repolarization. Vassalle et al. Reported that ouabain is more specific for cardiac fibers than cardiac fibers. Poisoning is mainly manifested as 4 phase addition to pole gradient increases, causing extra-term contraction and sustained