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目的 探讨苦参碱注射液肌注治疗慢性乙型肝炎的效果。方法 选择120例经临床或肝活检病理确诊的慢性乙型肝炎患者,随机分为2组(各60例);(1)对照组给予常规保肝药包括肝泰乐、肌苷、齐墩果酸片和复合维生素等治疗;(2)苦参碱组除了常规保肝药物外,加苦参碱注射液100mg,肌注,每日1次,疗程均为3个月。结果 苦参碱组临床症状和体征改善率、肝功能复常率、HBeAg和HBV DNA转阴率以及总有效率均明显优于对照组(P<0.01或<0.05)。结论 苦参碱注射液对促进肝功能恢复和抑制乙肝病毒复制等均有一定效果。
Objective To investigate the effect of intramuscular injection of matrine injection in the treatment of chronic hepatitis B. Methods A total of 120 patients with chronic hepatitis B who were diagnosed clinically or biopsy by pathology were randomly divided into 2 groups (60 in each). (1) The control group received conventional hepatoprotective drugs, including heptachlor, inosine, Acid tablets and vitamins and other treatment; (2) matrine group in addition to conventional liver drugs, add matrine injection 100mg, intramuscular injection, 1 day, treatment were 3 months. Results Matrine group clinical symptoms and signs of improvement, the rate of normal liver function, HBeAg and HBV DNA negative rate and the total effective rate was significantly better than the control group (P <0.01 or <0.05). Conclusion Matrine injection can promote the recovery of liver function and inhibit the replication of hepatitis B virus and so on.