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卵巢功能衰竭是不可逆的。一些卵巢早衰(POF)患者核型正常,病因不明,称之为特发性POF。以血清卵泡刺激素(FSH)、雌二醇(E2)、抑制素B(INHB)水平预测POF患者卵巢储备存在局限性。最近研究表明,血清抗苗勒管激素(AMH)能更精确地反映卵巢存在的卵泡。通过分析POF患者血清AMH水平与卵巢组织学特征的关系及卵巢AMH免疫学表达,探讨AMH评价POF患者存留卵泡及受孕的可能性,同时探讨卵巢功能紊乱的可能机制。
Ovarian failure is irreversible. Some patients with premature ovarian failure (POF) normal karyotype, etiology, called idiopathic POF. The prediction of ovarian reserve in patients with POF is limited by the levels of serum follicle stimulating hormone (FSH), estradiol (E2) and inhibin B (INHB). Recent studies have shown that serum anti-Mullerian hormone (AMH) can more accurately reflect the presence of ovarian follicles. By analyzing the relationship between AMH level in ovarian tissues and the histological characteristics of ovarian tissue and the immunological expression of AMH in ovary, the possible mechanism of AMH in evaluating the persistence of follicles and conception in POF patients was explored, and the possible mechanism of ovarian dysfunction was discussed.