长春瑞滨(NVB)又名异长春花碱,是一种半合成的长春花生物碱,主要用于治疗非小细胞肺癌、乳腺癌、食管癌、卵巢癌和恶性淋巴瘤等。但长春瑞滨对血管、局部皮肤和组织的刺激性很大,静脉炎发生率较高[1-3],不但给患者带来痛苦而且严重影响化疗周期的顺利完成。虽然深静脉置管可有 Vinorelbine (NVB), also known as vincristine, is a semi-synthetic vinca alkaloid, mainly used for the treatment of non-small cell lung cancer, breast cancer, esophageal cancer, ovarian cancer and malignant lymphoma. However, vinorelbine is highly irritating to the blood vessels, local skin and tissues and has a high incidence of phlebitis [1-3], which not only causes pain to the patients but also seriously affects the successful completion of the chemotherapy cycle. Although deep vein catheterization may have