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和一般合成生物降解聚合物不同,不用催化剂,将L-乳酸与芳香羟基酸如对-羟基苯甲酸(HBA)、对-羟基苯乙酸(HPAA)、对- 羟基苯丙酸(HPPA)和DL-苦杏仁酸(MA)在溶液中通氮气,200℃缩聚20 h合成低分子量共聚物,选择雌莫司汀(estramustine)作为抗癌药模型制成植入剂。方法是将20 mg药物粉末和80 mg共聚物粉末混合,在100℃熔融得均匀混合物,冷至室温,粉碎。将粉碎物装入内径为3 mm的聚四
Unlike conventional synthetic biodegradable polymers, L-lactic acid and aromatic hydroxy acids such as p-hydroxybenzoic acid (HPA), p-hydroxyphenyl acetic acid (HPPA) and DL - Mandelic acid (MA) through the solution of nitrogen, polycondensation at 200 ℃ for 20 h synthesis of low molecular weight copolymer, choose estramustine (estramustine) as an anticancer drug model made implants. The procedure is to mix 20 mg of drug powder with 80 mg of copolymer powder, melt at 100 ° C to obtain a homogeneous mixture, cool to room temperature and grind. The crushed material into the inner diameter of 3 mm poly four