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目的:研究钙网蛋白(CRT)在不同病理分型大肠癌患者中的表达及探讨其与大肠癌的关系。方法:大肠癌患者150例,按照病理分型分为4组:高分化腺癌组、中分化腺癌组、低分化腺癌组、黏液腺癌组,同时设立健康对照组。ELISA法检测血清CRT含量。结果:大肠癌患者血清CRT含量远较健康对照组高,差异有统计学意义(P=0.00)。其中不同病理分型的大肠癌患者CRT含量也不完全相同。高、中分化腺癌组之间比较差异无统计学意义(P=0.057),但与低分化腺癌组及黏液腺癌组比较差异有统计学意义(P=0.00),而低分化腺癌组及黏液腺癌组之间比较差异无统计学意义(P=0.10)。结论:大肠癌细胞存在CRT的过度表达,且CRT表达水平能够评估大肠癌患者的预后。
Objective: To study the expression of calreticulin (CRT) in patients with different pathological types of colorectal cancer and its relationship with colorectal cancer. Methods: One hundred and fifty patients with colorectal cancer were divided into four groups according to the pathological classification: well-differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma, and mucinous adenocarcinoma. At the same time, a healthy control group was established. Serum CRT was detected by ELISA. Results: The serum levels of CRT in patients with colorectal cancer were significantly higher than those in healthy controls (P = 0.00). The different pathological types of colorectal cancer patients with CRT content is not exactly the same. There was no significant difference between high and moderately differentiated adenocarcinoma group (P = 0.057), but there was a significant difference between poorly differentiated adenocarcinoma group and mucinous adenocarcinoma group (P = 0.00), while poorly differentiated adenocarcinoma There was no significant difference between the two groups (P = 0.10). Conclusion: CRT is overexpressed in colorectal cancer cells and the expression of CRT can assess the prognosis of patients with colorectal cancer.