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实验用杂种成年犬24条,随机分成蛇毒抗栓酶(Svate)组、尿激酶(UK)组及生理盐水对照组,每组8条。麻醉后开胸,以微量直流电刺激冠脉外膜致冠脉内血栓形成,4小时后经静脉各组分别注射Svate 0.2u/kg、UK10000u/kg和等量生理盐水。以冠脉造影作为血栓形成及血管再通指标。在电刺激前,冠脉血栓形成后及给药后采血测血浆丙二醛(MDA)含量,最后摘出心脏,采样测心肌MDA含量。结果表明Svate能溶解冠脉血栓,具有抑制脂质过氧化作用并能减轻再灌注心肌损害。
Twenty-four adult hybrid dogs were randomly divided into three groups: control group (Svate), urokinase (UK) and saline control group. Thoracotomy was performed after anesthesia. Coronary thrombus formation was induced by micro-dc to coronary epicardium. Svate 0.2u / kg, UK10000u / kg and equal volume of saline were injected into each group after 4 hours. Coronary angiography as an index of thrombosis and recanalization. Before electrical stimulation, after coronary thrombosis and after administration of blood plasma concentration of malondialdehyde (MDA) content, the final removal of the heart, myocardial MDA content sampling. The results show that Svate can dissolve coronary thrombosis, with inhibition of lipid peroxidation and can reduce myocardial reperfusion injury.