血卟啉衍生物(HPD)光化学疗法已用来治疗人体恶性肿瘤。静脉注射的 HPD 能够选择性地滞留于肿瘤内,并被红光(约630nm)激活。肿瘤受到破坏一般认为是由于释放出单态氧。迄今所报道的唯一主要的副作用是皮肤光敏反应。HPD 是卟啉类的复杂混合物.在组织培养试验中聚集的卟啉光毒反应最强,含有乙烯基支链的卟啉也有较强的光毒作用。本文作者在移植性小鼠肿瘤模型上,研究了卟啉类组份的光毒及皮肤致敏能力,并用足跖检定的方法研究了皮肤的光敏性.方法:小鼠肿瘤试验,采用 Lewis 肺癌细胞,每 Hematoporphyrin derivative (HPD) photochemotherapy has been used to treat human malignancy. Intravenous HPD can be selectively retained in the tumor and activated by red light (approximately 630 nm). The destruction of tumors is generally thought to be due to the release of singlet oxygen. The only major side effect reported so far is skin photosensitivity. HPD is a complex mixture of porphyrins. The phototoxicity of porphyrins aggregated in tissue culture experiments is the strongest, and porphyrins containing vinyl branches also have strong phototoxic effects. The authors studied phototoxicity and skin sensitization of porphyrins on a transplantable mouse tumor model, and studied the photosensitivity of the skin with a foot-stool assay. Methods: Mouse tumor test with Lewis lung cancer Cells, each