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本文较详细地介绍了目前国内外学者关注的兴奋性氨基酸的神经毒性作用及其在缺血缺氧性脑损伤中的作用机理,认为钙内流介导了兴奋性氨基酸递质在缺血缺氧性脑损伤中的毒性作用,且进一步阐明了兴奋性氨基酸递质诱发钙内流的主要途径,总结和探讨了兴奋性氨基酸受体拮抗剂在保护缺血缺氧性脑损伤方面的作用及其今后的发展前景。
This article describes in more detail the neurotoxicity of excitatory amino acids and its mechanism of action in hypoxic-ischemic brain damage in China and abroad. It is believed that calcium influx mediates the neurotransmitter of excitatory amino acids in ischemia Oxygenated brain injury in toxic effects, and further clarify the excitatory amino acid neurotransmitter-induced calcium influx of the main ways to sum up and explore the excitatory amino acid receptor antagonists in the protection of hypoxic-ischemic brain damage in the role and Its future development prospects.