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目的通过分析某院86例冠心病合并高血压患者血浆中心房钠尿肽(BNP)的高低研究其与冠心病、高血压发病的相关性,为临床诊断、治疗提高相关性依据。方法选择该院2011年5月～2011年10月收治的86例冠心病(和或)高血压患者做为观察对象,其中患高血压不患冠心病的患者35例,仅患冠心病的患者22例,冠心病合并高血压患者29例,将所有患者出入院的资料录入Excel,分为3组进行讨论,使用SPSS18.0对不同疾病患者进行体内BNP水平与血压、血浆低密度脂蛋白、甘油三酯、总胆固醇、血糖、体重、吸烟按照逐步分析原则进行Logistics回归性统计分析。结果血糖超标、总胆固醇、甘油三酯水平超标是单纯高血压组BNP水平升高的危险因素(OR=2.21,2.22,1.84,P﹤0.01);单纯冠心病组BNP升高的危险因素分别为:低密度脂蛋白异常、高密度脂蛋白异常、总胆固醇偏高、吸烟、血压升高(OR=1.11,0.91,0.24,1.37,1.32,P﹤0.01);冠心病合并高血压组的BNP水平偏高的危险因素包括:血压、血糖、体重、吸烟、低密度脂蛋白,高血压合并冠心病组BNP浓度(109.2±87.2)均高于其他两组(F=1.241,P﹤0.01)。结论冠心病、高血压病患者某些因素是其致病的重要原因,而BNP的高低又与这些致病危险的高低存在显著相关性,BNP可以做为预测冠心病、高血压病患者疾病严重程度,同时可以做为临床治疗水平高低的有效指标。
Objective To investigate the relationship between plasma atrial natriuretic peptide (BNP) and coronary heart disease and hypertension in 86 patients with coronary heart disease complicated with hypertension and to provide basis for clinical diagnosis and treatment. Methods Eighty-six patients with CHD (or hypertension) admitted to our hospital from May 2011 to October 2011 were enrolled in the study. Among them, 35 patients had hypertension without coronary heart disease, and only patients with coronary heart disease 22 cases of coronary heart disease with hypertension in 29 cases, all patients access to hospital data entry Excel, divided into three groups to discuss the use of SPSS18.0 for different diseases in patients with BNP levels and blood pressure, plasma low density lipoprotein, The triglyceride, total cholesterol, blood sugar, body weight, smoking were statistically analyzed by Logistics regression according to the principle of stepwise analysis. Results Excessive blood glucose, total cholesterol and triglyceride levels were the risk factors for elevated BNP levels in patients with hypertension (OR = 2.21,2.22,1.84, P <0.01). The risk factors for elevated BNP in patients with coronary heart disease were (OR = 1.11,0.91,0.24,1.37,1.32, P <0.01); BNP levels in CHD with hypertension group were significantly higher than those in control group High risk factors include: blood pressure, blood glucose, body weight, smoking, low density lipoprotein, hypertension with coronary heart disease BNP concentration (109.2 ± 87.2) were higher than the other two groups (F = 1.241, P <0.01). Conclusion Some factors of coronary heart disease and hypertension are the important reasons of its pathogenesis. However, the level of BNP is significantly correlated with the risk of these diseases. BNP can be used as a predictor of coronary heart disease and hypertension. Degree, at the same time can be used as an effective indicator of the level of clinical treatment.