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经低剂量X射线照射后,荷瘤小鼠肺转移结节明显减少;与低剂量环磷酰胺(CY)合用后也可使荷瘤小鼠的肺转移结节减少。对小鼠体内免疫功能检测研究表明:小鼠脾脏细胞(NK)活性,LAK活性以及对白细胞介素-2(IL-2)的反应性均显著增强;当与低剂量CY合用时,上述抗肿瘤免疫功能也提高,可见低水平照射能通过有效地激活体内抗肿瘤免疫功能而具有显著的抗转移效果,它为探讨低水平电离辐射临床应用可能性提供了较为可靠的实验依据。
After low-dose X-ray irradiation, tumor-bearing mice significantly reduced lung metastasis nodules; combination with low-dose cyclophosphamide (CY) can also reduce tumor-bearing mice lung metastasis. The study of immune function in mice showed that the activity of NK cells, LAK activity and the reactivity to interleukin-2 (IL-2) in mice were significantly increased. When combined with low dose of CY, Tumor immune function also increased, showing that low-level irradiation can have a significant anti-metastatic effect by effectively activating anti-tumor immune function in vivo, which provides a more reliable experimental basis for exploring the clinical application possibility of low-level ionizing radiation.