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目的 :探讨血小板表面凝血酶敏感蛋白 (TSP)、CD3 6表达改变与急性缺血性脑血管病关系。方法 :应用流式细胞术测定 10 9例脑缺血患者发病 48h内血小板TSP和CD3 6。结果 :(1)脑血栓形成和腔隙性脑梗死患者TSP明显较健康对照组增高。脑血栓形成者CD3 6增高。 (2 )TSP与不包括脑栓塞的脑梗死容积呈正相关 ,TSP与CD3 6、CD62p呈正相关。结论 :TSP可作为血小板活化指标 ,在脑血栓形成和腔隙性脑梗死中明显增高
Objective: To investigate the relationship between the changes of platelet surface thrombospondin (TSP) and CD3 6 expression and acute ischemic cerebrovascular disease. Methods: Flow cytometry was used to determine the platelet TSP and CD3 6 in patients with focal cerebral ischemia within 48 hours. Results: (1) TSP in patients with cerebral thrombosis and lacunar infarction was significantly higher than that in healthy controls. Cerebral thrombosis CD3 6 increased. (2) There was a positive correlation between TSP and cerebral infarction volume without cerebral embolism. TSP was positively correlated with CD3 6 and CD62p. Conclusion: TSP can be used as an index of platelet activation, which is significantly increased in cerebral thrombosis and lacunar infarction