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目的:探讨理气开郁法板块方对炎症介质影响的相对特征性作用。方法:以过滤空气皮下注射和1%角叉菜胶囊内注射制备大鼠背部气囊炎症模型,用放免法检测炎性渗出液中IL-6和PGE2及血清皮质醇,用硝酸还原酶法测定渗出液中NO,预防性灌胃用药。结果:各板块方高、中、低剂量和氢化可的松均能显著降低大鼠气囊炎症渗出液中IL-6水平,金铃子散高剂量的作用有优于氢化可的松的趋势。金铃子散高、中、低剂量、芍甘汤高、中剂量、柴郁汤中剂量及氢化可的松均能显著降低大鼠气囊炎症渗出液中PGE2水平,金铃子散和芍甘汤高、中剂量的作用与氢化可的松相当。金铃子散、芍甘汤、柴郁汤高、中、低剂量、痛泻要方中剂量和氢化可的松均能显著降低大鼠气囊炎症渗出液中NO含量,金铃子散高、中、低剂量、芍甘汤高剂量、柴郁汤中、高剂量的作用尤著。模型对照组大鼠血清皮质醇水平明显升高,氢化可的松组与芍甘汤低、中剂量组血清皮质醇明显降低。结论:金铃子散、痛泻要方降低IL-6的作用较强;金铃子散、芍甘汤降低PGE2的作用较强;金铃子散和柴郁汤降低NO的作用较强;四方中金铃子散的抗炎作用可能最强;芍甘汤的抗炎作用可能还涉及到皮质醇。
Objective: To investigate the relative characteristic effects of qi-qi-decoction method on inflammatory mediators. Methods: Inflammatory models of rat dorsal airbags were prepared by subcutaneous injection of filtered air and intraperitoneal injection of 1% carrageenan. IL-6 and PGE2 levels in serum and inflammatory exudate were measured by radioimmunoassay and measured by nitrate reductase method. Exudate NO, prophylactic gavage medication. Results: The high, medium, and low dosages of hydrocortisone in each block could significantly reduce the level of IL-6 in the balloon inflammatory exudate of rats. The effect of high dose of Jinlingzi powder was better than that of hydrocortisone. . The high-, middle-, and low-dose Jinlingzi powder, high-and medium-dose Zhigan decoction, medium dose of Chaiyu decoction, and hydrocortisone all significantly reduced PGE2 levels in airway inflammation exudates of rats. The effect of high and medium doses of Gantang is comparable to hydrocortisone. The effects of high dose, middle dose and low dose of Jinlingzi San, Qingan Decoction, and Chaiyu Decoction, middle dose of Tongxie Yaofang and hydrocortisone can significantly reduce the content of NO in the airway inflammation exudate of rats. The use of high doses of high doses of Shaogan Decoction, medium and low doses, and medium and high doses of Chai Yu Decoction are particularly important. The level of serum cortisol in the model control group was significantly increased, and the serum cortisol levels in the hydrocortisone group and the Zhigan Decoction low- and middle-dose group were significantly lower. Conclusion: Jinlingzi Powder and Tongxie Yaofang have a stronger effect on reducing IL-6; Jin Ling Zi San and Qi Gan Tang have a stronger effect on reducing PGE2; Jin Ling Zi San and Chai Yu Decoction have a stronger effect on reducing NO; The anti-inflammatory effects of Sifang Zhongjin Lingzi Powder may be the strongest; the anti-inflammatory effects of Qingan Decoction may also involve cortisol.