慢性肝脏损害常伴有肝纤维化改变;即细胞间基质成份胶原蛋白质和葡萄糖胺基多糖以及非胶原性结构物质糖蛋白的组织学从新分布积聚和分子排列紊乱。后一类型基质蛋白中的一个重要成份为层粘素(或层粘蛋白),这是从EHS小鼠肉瘤中分离出来的一种高分子量粘附性糖蛋白,后来发现它和Ⅳ型胶原与硫酸类肝素蛋白多糖一起构成所有基底膜的一种主要成份。肝脏纤维化改变的特征为沿肝窦周围新的基底膜形成,后者为窦内或窦周纤维化的主要特征,它使肝内血流动力学阻力和门静脉压力升高。应用敏感的放免法测定层粘素及其胃蛋白酶拮抗段片PI,发现在肝纤维化患者血 Chronic liver damage is often accompanied by changes in hepatic fibrosis; that is, the histology of interstitial collagen and glucosaminoglycans and non-collagenous structural glycoproteins re-accumulates and the molecular arrangement is disturbed. An important component of the latter type of stromal protein is laminin (or laminin), a high molecular weight adherent glycoprotein isolated from EHS murine sarcoma, which was later found to be associated with type IV collagen and Heparin sulfate proteoglycans together form a major component of all basement membranes. Hepatic fibrosis is characterized by the formation of a new basement membrane around the sinusoids, the latter being a major feature of sinus or sinus fibrosis, which increases intrahepatic hemodynamic resistance and portal pressure. Application of sensitive radioimmunoassay determination of laminin and pepsin antagonistic section PI, found in patients with liver fibrosis