Objective:To observe the efficacy of Yiqi Huoxue Decoction in the treatment of patients with diabetic nephropathy (DN) stageⅢ with qi and yin deficiency and stasis and its effects on vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β1).Methods:Sixty patients with stage DN of Qi-yin deficiency and stasis type DN who were treated in the Endocrinology Department of the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from September 2018 to December 2019 were selected as the research subjects.The remainder method was used to divide them into 30 cases in the observation group and 30 cases in the control group. Patients in both groups were referred to the guidelines and expert consensus for general treatment of DN (hypogl- ycemic,antihypertensive,lipid-lowering,etc.).The control group was given pancreatic kallikrein enteric-coated tablets orally once,120U,3 times a day,and the observation group was given The traditional Chinese medicine Yiqi Huoxue Decoction was taken orally,one dose daily,twice a day in the ming and evening;the two groups intervened continuously for 8 weeks.Detect blood FPG,PBG,HbA1c,β2-MG,BUN,SCr,VEGF,TGF-β1,and urine mALB and UACR levels before and after treatment, and calculate eGFR before and after treatment in both groups; observe changes in TCM syndrome scores in the two groups,Compare its clinical efficacy.Results:After 8 weeks of treatment,the total clinical effective rate of patients in the observation group was 93.3％,which was significantly different from the control group of 76.6％ (P<0.05);the TCM syndrome scores in the observation group were significantly lower than those before treatment and in the control group (P<0.05); The levels of FPG,HbA1c,PPG,mALB,β2-MG,UACR, VEGF,and TGF-β1 in the observation group were significantly lower than those in the control group, with significant differences (P<0.05).The levels of SCr and BUN in the observation group were significantly lower. Compared with before treatment, eGFR increased, but there was no signi- ficant difference (P>0.05).Conclusion: Yiqi Huoxue Decoction for the treatment of patients with DN typeⅢqi-yin deficiency and stasis type,not only helps to lower blood sugar levels,improve TCM syndromes,but also can reduce early renal damage,reduce urine albumin, and delay kidney function It may be further worsened and has better safety. The mechanism may be related to reducing the levels of VEGF and TGF-β1,thereby delaying the fibrosis of tubulointerstitial scar and inhibi- ting glomerular capillary sclerosis.