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目的:探讨孕妇妊娠不同时期血浆D-二聚体和凝血四项的变化情况和临床意义。方法:对149例妊娠妇女分别在早期妊娠、中期妊娠、晚期妊娠和临产期进行D-二聚体和凝血四项检测,并对结果进行统计学分析。结果:D-二聚体在孕早期、孕中期、孕晚期至临产期呈进行性升高(P<0.01);凝血酶原时间(PT)在孕早期、孕中期至孕晚期进行性缩短(P<0.05),孕晚期至临产期无显著差异(P>0.05);凝血活酶时间(TT)在妊娠早期至临产期无统计学变化(P>0.05):活化部分凝血酶时间(APTT)孕早期至孕中期明显缩短(P<0.01),孕中期至孕晚期无统计学变化(P>0.05),孕晚期至临产期显著缩短(P<0.05);纤维蛋白原含量(FIB)在孕早期至孕中期显著升高(P<0.01),孕中期至孕晚期无统计学变化(P>0.05),晚期至临产期急剧升高(P<0.01)。结论:联合动态监测妊娠期D-二聚体和凝血四项对于减少产后出血及预防和治疗血栓性疾病有重要的临床价值。
Objective: To investigate the changes of plasma D-dimer and coagulation at different stages of pregnancy in pregnant women and its clinical significance. Methods: 149 pregnant women were tested for D-dimer and coagulation in early gestation, second trimester gestation, late gestation and laboring period, and the results were statistically analyzed. Results: D-dimer increased progressively from the first trimester to the second trimester (P <0.01). Prothrombin time (PT) shortened during the first trimester to the third trimester (P> 0.05). There was no significant difference between the third trimester and the first trimester of pregnancy (P> 0.05). The activity of thromboplastin time (APTT) (P <0.01). There was no significant difference between the second trimester and the third trimester (P> 0.05), and the third trimester was significantly shortened (P <0.05). The fibrinogen content (FIB) There was no significant difference between the second trimester and the third trimester of pregnancy (P> 0.05), and the rate was significantly increased from late pregnancy to the first trimester (P <0.01). Conclusion: The combination of dynamic monitoring of D-dimer and coagulation during pregnancy has important clinical value in reducing postpartum hemorrhage and preventing and treating thrombotic diseases.