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目的 探讨血清脂蛋白(a)———Lp(a)在急性脑梗死患者中的含量与脑梗死及梗死部位的关系。方法 采用酶联免疫吸附法检测100例急性脑梗死患者Lp(a)含量,并与正常对照组进行比较。结果 急性脑梗死患者血清中Lp(a)含量及其异常率显著高于对照组,且与发病部位有关,皮质支动脉闭塞显著高于深穿支动脉闭塞,Lp(a)含量与血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、血糖之间无相关性,不受性别、高血压、冠心病等危险因素的影响。结论 血清Lp(a)含量增高是急性脑梗死的重要的独立的危险因素。
Objective To investigate the relationship between serum lipoprotein (a) --- Lp (a) in patients with acute cerebral infarction and cerebral infarction and infarction. Methods The levels of Lp (a) in 100 patients with acute cerebral infarction were detected by enzyme-linked immunosorbent assay (ELISA) and compared with the normal control group. Results Serum levels of Lp (a) and its abnormalities in patients with acute cerebral infarction were significantly higher than those in the control group, and were related to the site of disease. The occlusion of cortical branches was significantly higher than that of deep perforating branches, the contents of Lp (a) and serum total cholesterol , Triglyceride, high density lipoprotein, low density lipoprotein, blood glucose, and no risk factors such as gender, hypertension and coronary heart disease. Conclusion The increase of serum Lp (a) level is an important and independent risk factor for acute cerebral infarction.