论文部分内容阅读
目的建立多元回归分光光度法同时测定复方对乙酰氨基酚片中乙酰水杨酸和对乙酰氨基酚。方法样品用0.2mol·L-1氢氧化钠水解乙酰水杨酸后,以pH 6.5磷酸二氢钾缓冲溶液为溶剂,采用多元回归分光光度法,测定波长为236,272和283nm。结果乙酰水杨酸和对乙酰氨基酚的平均回收率分别为98.9%和99.0%,RSD分别为2.4%和3.0%。结论样品测定结果与部颁标准法比较,其准确度和精密度无显著性差异,该法可同时准确测定复方对乙酰氨基酚片中乙酰水杨酸和对乙酰氨基酚的含量。
Objective To establish a multiplex regression spectrophotometric method for simultaneous determination of acetylsalicylic acid and acetaminophen in compound paracetamol tablets. Methods After hydrolyzing acetylsalicylic acid with 0.2 mol·L-1 sodium hydroxide, the sample was detected by multiple regression spectrophotometry with pH 6.5 potassium dihydrogen phosphate buffer solution. The wavelength was 236, 272 and 283 nm. Results The average recoveries of acetylsalicylic acid and acetaminophen were 98.9% and 99.0%, respectively, with RSDs of 2.4% and 3.0%, respectively. Conclusion The results of the determination of the sample compared with the ministerial standard method, the accuracy and precision of no significant difference, the method can be simultaneously accurate determination of acetaminophen tablets acetaminophen and acetaminophen content.