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80mg梳棉尘及代表其主要成份的脱脂棉尘80mg,含革兰氏阴性菌:取自100mg梳棉尘的提取液和4mg SiO_2间断、分次分组染尘大鼠1天至12月后病理观察表明:脱脂棉尘最初引起急性间质性炎症,继而形成异物型肉芽肿,至12月发展为纤维性细胞结节及病损区间质一定程度的纤维化,仅逊于梳棉尘组的严重程度,提取液和微量SiO_2不能造成广泛肺损伤,各染尘组BAL细胞成份变化趋势与病理改变同步,提示棉纤维所致异物性炎症是肺间质病变的主因.
80mg combed cotton dust and the main component of the denatured cotton dust 80mg, containing Gram-negative bacteria: 100mg combed cotton dust extract and 4mg SiO_2 intermittent, graded dust stained rats 1 day to 12 months after the pathological observation The results showed that: Absorbent cotton dust initially caused acute interstitial inflammation, and then formed foreign body granuloma, which developed to fibrosis of fibrous nodules and lesions in December to a certain degree, which was only inferior to that of combing cotton dust group Degree, extract and trace SiO 2 could not cause extensive lung injury. The trend of BAL cell components in all the dyed groups was synchronized with the pathological changes, suggesting that foreign body inflammation caused by cotton fiber is the main cause of interstitial lung disease.