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目的:探讨抚触联合综合治疗、高压氧联合综合治疗和单纯综合治疗对新生儿缺氧缺血性脑病(HIE)的疗效影响。方法:参照美国1996年Pediatrics中HIE的诊断标准,对随机分成3组的HIE患儿分别采用综合治疗(A组)、高压氧联合综合治疗(B组)和抚触联合综合治疗(C组)进行治疗,并行NBNA20项神经行为评分、精神运动发育商(DQ)评估和伤残率比较,判断疗效。结果:新生儿期NBNA评分3组无明显差异(P均>0.05),后期DQ评分和伤残率比较A组和B组无显著性差异(P>0.05),而C组明显优于A组与B组,差异有显著性(P<0.01,P<0.01)。结论:抚触联合综合措施治疗HIE,疗效确切,能明显改善HIE患儿的预后。
Objective: To investigate the effect of combined touch therapy, hyperbaric oxygen therapy and simple combination therapy on neonatal hypoxic-ischemic encephalopathy (HIE). Methods: According to the diagnostic criteria of HIE in Pediatrics in 1996 in the United States, comprehensive treatment (group A), combination of hyperbaric oxygen therapy (group B) and combination therapy (group C) were randomly divided into three groups. After treatment, NBNA20 neurobehavioral scores, psychomotor developmental (DQ) assessment and disability rates were compared to determine the efficacy. Results: There was no significant difference in Neonatal NBNA score among the three groups (P> 0.05), while there was no significant difference between the late DQ score and the disability rate in Group A and Group B (P> 0.05) Compared with group B, the difference was significant (P <0.01, P <0.01). Conclusion: The combination of touch and comprehensive treatment of HIE is effective and can significantly improve the prognosis of children with HIE.