An inverted pendulum is a sensitive system of highly coupled parameters, in laboratories, it is popular for modelling nonlinear systems such as mechanisms and control systems, and also for optimizing programmes before those programmes are applied in real situations. This study aims to find the optimum input setting for a double inverted pendulum(DIP), which requires an appropriate input to be able to stand and to achieve robust stability even when the system model is unknown. Such a DIP input could be widely applied in engineering fields for optimizing unknown systems with a limited budget. Previous studies have used various mathematical approaches to optimize settings for DIP, then have designed control algorithms or physical mathematical models.This study did not adopt a mathematical approach for the DIP controller because our DIP has five input parameters within its nondeterministic system model. This paper proposes a novel algorithm, named Uni Neuro, that integrates neural networks(NNs) and a uniform design(UD) in a model formed by input and response to the experimental data(metamodel). We employed a hybrid UD multiobjective genetic algorithm(HUDMOGA) for obtaining the optimized setting input parameters. The UD was also embedded in the HUDMOGA for enriching the solution set, whereas each chromosome used for crossover, mutation, and generation of the UD was determined through a selection procedure and derived individually. Subsequently, we combined the Euclidean distance and Pareto front to improve the performance of the algorithm. Finally, DIP equipment was used to confirm the settings. The proposed algorithm can produce 9 alternative configured input parameter values to swing-up then standing in robust stability of the DIP from only 25 training data items and 20 optimized simulation results. In comparison to the full factorial design, this design can save considerable experiment time because the metamodel can be formed by only 25 experiments using the UD. Furthermore, the proposed algorithm can be applied to nonlinear systems with multiple constraints. An inverted pendulum is a sensitive system of highly coupled parameters, in laboratories, it is popular for modelling nonlinear systems such as mechanisms and control systems, and also for optimizing programs before those programs are applied in real situations. This study aims to find the optimum input setting for a double inverted pendulum (DIP), which requires an appropriate input to be able to stand and to achieve robust stability even when the system model is unknown. Such a DIP input could be widely applied in engineering fields for optimizing unknown systems with Previous studies have used various algorithms to optimize settings for DIP, then have designed control algorithms or physical mathematical models. This study did not adopt a mathematical approach for the DIP controller because our DIP has five input parameters within its nondeterministic system This paper proposes a novel algorithm, named Uni Neuro, that integrates neural networks (NNs) and a uniform design (UD) in a model formed by input and response to the experimental data (metamodel). We employed a hybrid UD multiobjective genetic algorithm (HUDMOGA) for obtaining the optimized setting input parameters. The UD was also embedded in the HUDMOGA for enriching the solution set, each each used for crossover, mutation, and generation of the UD was determined through a selection procedure and derived individually. Finally, DIP equipment was used to confirm the settings. The proposed algorithm can produce 9 alternative configured input parameter values ​​to swing-up then standing in robust stability of the DIP from only 25 training data items and 20 optimized simulation results. the full factorial design, this design can save considerable experiment time because the metamodel can be formed by only 25 experiments using the UD. Furthermore, the proposed algorithm can be applied to nonlinear systems with multiple constraints.