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目的:探讨罕见前列腺混合型肿瘤的诊断及治疗。方法:回顾性分析本院1995年2月至2008年2月确诊的6例前列腺混合型肿瘤患者的临床资料并结合文献讨论。结果:3例(前列腺混合型小细胞癌和腺癌2例,前列腺腺鳞癌1例)行姑息性TUVP术及内分泌治疗,均于7～10个月死亡。3例(前列腺腺鳞癌2例,前列腺癌肉瘤1例)予以膀胱、前列腺切除并尿流改道,无瘤生存时间均超过1年,2例仍处于随访中。结论:前列腺混合型恶性肿瘤预后差,确诊需经详细病检及免疫组化技术,根治性手术是目前治疗前列腺混合型肿瘤较有效的措施。
Objective: To investigate the diagnosis and treatment of rare prostate mixed tumor. Methods: The clinical data of 6 patients with mixed prostate tumor confirmed from February 1995 to February 2008 in our hospital were retrospectively analyzed and discussed. Results: Palliative TUVP and endocrine therapy were performed in 3 cases (2 small cell carcinoma and adenocarcinoma of the prostate and 1 adenosquamous adenocarcinoma of the prostate), both of which died within 7-10 months. Three cases (2 cases of adenosquamous adenocarcinoma of the prostate and 1 case of prostate carcinoid) were treated by bladder resection and prostatic resection and urinary diversion. The survival time was longer than 1 year and 2 cases were still under follow-up. Conclusions: Prostate mixed malignancies have poor prognosis and confirmed by detailed pathological examination and immunohistochemistry. Radical surgery is the most effective measure for the treatment of mixed prostate cancer.