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家兔感染日本血吸虫尾蚴后第8周,其肝内胶原含量增加至正常值的2倍,11周时为正常值的3倍;杀虫治疗后14周仍为正常值的2.5倍左右。血清MAO活性在第4周已显著增高,杀虫治疗后便回复到正常范围。肝组织胶原活性在第8周时,显著高于正常值(P<0.05),11周时显著下降,18周(杀虫治疗后1周)对进一步低下,显著低于正常值(P<0.01)。肝组织胶原酶活性与肝内胶原含量之间呈显著的负相关(r=-0.647,P<0.01).表明血吸虫病肝纤维化形成过程中肝内胶原代谢的异常,似与血吸虫卵引起的肉芽肿免疫反应密切相关。提示对于血吸虫病肝纤维化,除给予病原治疗外,尚须设法提高肝组织胶原酶活性,促进已沉积于肝内胶原的分解。
Rabbit infected with Schistosoma japonicum cercariae after 8 weeks, the liver collagen content increased to 2 times the normal, 11 weeks to 3 times the normal value; 14 weeks after insecticide treatment is still 2.5 times the normal value. Serum MAO activity in the fourth week has been significantly higher, insecticidal treatment will return to the normal range. The activity of collagen in hepatic tissue was significantly higher than the normal value at the 8th week (P <0.05), significantly decreased at 11 weeks and further lower at 18 weeks (1 week after the pesticide treatment), significantly lower than the normal value (P <0.01) ). Liver tissue collagenase activity and intrahepatic collagen content was significantly negatively correlated (r = -0.647, P <0.01), indicating that schistosomiasis hepatic fibrosis during liver collagen metabolism abnormalities, it seems and schistosome eggs caused Granuloma immune response is closely related. Tip for schistosomiasis liver fibrosis, in addition to the pathogen treatment, we still have to try to improve liver collagenase activity, and promote the deposition of collagen in the liver decomposition.