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7-氨基头孢烷酸为原料采用“一锅煮”的方法合成关键中间7β-胺基-3-[3-胺基-2-(2-羟乙基)-1-吡唑嗡甲基]-3-头孢烯-4-羧酸盐酸盐,再与2-(2-氨基-4-噻唑基)-2-(甲氧亚氨基)乙酸硫代苯并噻唑酯缩合得到头孢噻利。
7-amino-cephalosporanic acid as the raw material using “one-pot” method for the synthesis of the key intermediate 7β-amino-3- [3-amino-2- -3-cephem-4-carboxylic acid hydrochloride, followed by condensation with 2- (2-amino-4-thiazolyl) -2- (methoxyimino) acetic acid thiobenzothiazole ester.