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目的:分析肠毒清口服液对全身炎症反应综合征(SIRS)大鼠血清和肺泡灌洗液中脑钠素(BNP)水平的影响,探讨肠毒清口服液治疗SIRS的机制。方法:将72只雄性SD大鼠随机分为9组(n=8)。腹腔注射(ip)酵母多糖悬浊液(ZPS)制造SIRS模型(A模型组用750 mg/kg ZPS造模;B模型组用1 000 mg/kg ZPS造模),对照组用NS灌胃(ig),A、B低、中、高剂量组分别ig低、中、高剂量的肠毒清口服液。末次给药后第3天处死,测血清和肺泡灌洗液中BNP水平。结果:各组均现一般状况恶化,但模型组较轻;A、B模型组血清和肺泡灌洗液中BNP含量普遍高于中、高剂量组,随药物浓度增加BNP水平呈下降趋势,且高剂量组与模型组比较有显著性差异(P<0.05)。结论:较高剂量的肠毒清口服液通过降低大鼠血清和肺泡灌洗液中BNP的含量缓解SIRS引起的心衰,延缓SIRS发展为多器官功能障碍综合征(MODS)。
Objective: To investigate the effect of Changduqing oral liquid on the level of brain natriuretic peptide (BNP) in serum and alveolar lavage fluid in rats with systemic inflammatory response syndrome (SIRS), and to explore the mechanism of Gutanqing oral liquid in treating SIRS. Methods: Seventy-two male SD rats were randomly divided into 9 groups (n = 8). The SIRS model was established by intraperitoneal injection of zymosan suspension (ZPS) (model A was treated with 750 mg / kg ZPS and model B was treated with 1000 mg / kg ZPS) ig), A, B low, medium and high dose groups were ig low, medium and high doses of enterotoxin oral solution. The third day after the last administration, sacrifice, serum and alveolar lavage fluid BNP levels. Results: BNP levels in serum and alveolar lavage of group A and B were generally higher than that of medium and high dose groups, but BNP level decreased with the increase of drug concentration There was a significant difference between high dose group and model group (P <0.05). Conclusions: The higher dose of gingduqing oral liquid can relieve the SIRS-induced heart failure and delay the development of SIRS to multiple organ dysfunction syndrome (MODS) by reducing the content of BNP in rat serum and bronchoalveolar lavage fluid.