美洲商陆抗病毒蛋白(PAP)是从美洲商陆Phytolacca americana中分离出的分子量为29kDa的植物蛋白,具有广谱抗病毒作用。由于具体内强抗HIV活性,且不干扰体内精子功能和对生殖道上皮细胞不产生毒性,而成为非杀精子的杀微生物活性成分,显示了独特的临床潜力。作者进行了1项为期13周的亚慢性毒性试验,研究了PAP凝胶对小鼠阴道给药是否产生潜在的生殖毒性。 Pokeweed Antiviral Protein (PAP) is a plant protein with a molecular weight of 29 kDa isolated from Phytolacca americana, and has a broad-spectrum antiviral effect. Due to the specific internal anti-HIV activity, which does not interfere with sperm function in the body and does not produce toxicity to the genital tract epithelial cells, it becomes a microbicidal active ingredient of non-spermicidal sperm, showing unique clinical potential. The authors conducted a 13-week subchronic toxicity study to investigate whether the PAP gel produced potential reproductive toxicity in mice following vaginal administration.