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为探讨特异性血管紧张素Ⅱ受体 1阻断剂氯沙坦调节高血压血管重塑与细胞外信号调节激酶的关系 ,本文采用两肾一夹型高血压大鼠为动物模型 ,术后第 2、4、6周测血压 ,6周后处死大鼠称心脏重量 ,取胸主动脉和肠系膜动脉作形态学观察和计算机图像分析 ,免疫印迹方法检测主动脉中磷酸化细胞外信号调节激酶及总细胞外信号调节激酶的表达。结果发现 ,与假手术对照组相比 ,模型组大鼠血压和心脏与体重之比分别增加 5 0 %和 48%(P均 <0 .0 1) ,主动脉和肠系膜动脉的内径与中膜厚度之比明显减少 (分别为 7.10± 0 .5 9比 9.2 4± 1.17,6.0 0± 0 .89比 8.96± 1.2 3 ) ,中膜厚度明显增加 (分别为 119.47± 10 .77μm比 91.5 5± 14.45 μm ,49.60± 1.0 4μm比 3 7.0 1± 4.85 μm ,P均 <0 .0 5 ) ,主动脉中磷酸化细胞外信号调节激酶的表达显著增强 ;氯沙坦治疗后 ,血压、心脏与体重之比分别下降到 13 2± 9mmHg、0 .3 2± 0 .0 3 (P均 <0 .0 5 ) ,主动脉和肠系膜动脉的内径与中膜厚度之比明显增加 ,中膜厚度明显减小 ,并下调主动脉中磷酸化细胞外信号调节激酶的表达。提示氯沙坦可明显改善两肾一夹型高血压大鼠的血管重塑 ,这种调节可能是通过细胞外信号调节激酶信号途经发挥作用的
In order to investigate the relationship between losartan and vascular remodeling induced by specific angiotensin Ⅱ receptor-1 blocker and extracellular signal-regulated kinase, two kidney-clip hypertensive rats were used as animal models. The blood pressure was measured at 2, 4, and 6 weeks after operation. The heart weight of rats was sacrificed 6 weeks later. The morphology of the thoracic and mesenteric arteries was observed and analyzed by computer image analysis. The phosphorylated extracellular signal - regulated kinases in the aorta and Total extracellular signal-regulated kinase expression. The results showed that compared with the sham-operated control group, the blood pressure and heart-to-body weight ratio increased by 50% and 48% in model group (P <0.01), and the diameter of the aorta and mesenteric artery (7.10 ± 0.59 vs 9.24 ± 1.17, 6.00 ± 0.89 vs 8.96 ± 1.2 3, respectively) and a significant increase in the thickness of the tunica media (119.47 ± 10.77 μm vs 91.5 5 ± 14.45 μm, 49.60 ± 1.0 4μm vs 3 7.01 ± 4.85 μm, P <0.05). The expression of phosphorylated extracellular signal-regulated kinase in the aorta was significantly increased. After treatment with losartan, blood pressure, heart and body weight (P <0.05), the ratio of the diameter of the aorta and the mesenteric artery to the thickness of the tunica media significantly increased, and the thickness of the tunica media significantly decreased Small, and downregulated phosphorylated extracellular signal-regulated kinase in the aorta. These results suggest that losartan can significantly improve vascular remodeling in two-kidney-one type of hypertensive rats, which may play a role through the extracellular signal-regulated kinase signaling pathway