本文作者为了评价联合甲、乙型肝炎疫苗对15至18岁健康者的免疫原性和反应原性而采用双盲随机的临床研究方法。疫苗分别于第0、1、6月在三角肌内注射,免疫原性的评估是通过在第一剂疫苗使用后的第2、6、7月检测抗-HBs抗体水平;反应原性的评估是通过每剂疫苗使用后3天内的各种反应。 The authors used a double-blind, randomized clinical trial to evaluate the immunogenicity and reactivity of the combination of hepatitis A and B vaccine in healthy individuals aged 15 to 18 years. Vaccines were injected intra-deltoid intramuscularly at 0, 1, and 6, respectively, and immunogenicity was assessed by measuring anti-HBs antibody levels at months 2, 6, and 7 after the first dose of vaccine; assessment of the reactivity It is through a variety of reactions within 3 days after each dose of vaccine is used.