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目的探讨黄葵胶囊对儿童哮喘的临床疗效及其机制。方法共计88例支气管哮喘患儿纳入研究,并随机分为两组:对照组(n=38)与干预组(n=50)。所有患儿均给予抗炎、化痰、平喘等常规治疗。干预组在上述治疗的基础上加用黄葵胶囊治疗。记录两组症状体征、肺功能(FEV1、PEF)、嗜酸粒细胞、血清炎症因子、IgE水平。结果对照组总有效率为92.1%,干预组总有效率为92.0%,但后者显效率更高(P<0.05)。经过治疗后,两组患者的肺功能均有好转,但差异无统计学意义(P>0.05);两组嗜酸粒细胞、血清炎症因子及IgE水平均降低(P<0.01),干预组更为明显(P<0.05),差异均有统计学意义。结论黄葵胶囊可以增加治疗后的显效率,降低体内的炎症水平,提高免疫力,但对肺功能影响不大。
Objective To investigate the clinical efficacy and mechanism of Huang Kui Capsule in children with asthma. Methods A total of 88 children with bronchial asthma were enrolled and randomly divided into two groups: control group (n = 38) and intervention group (n = 50). All children were given anti-inflammatory, phlegm, asthma and other conventional treatment. Intervention group on the basis of the above treatment with Huang Kui capsule treatment. Two groups of symptoms and signs, pulmonary function (FEV1, PEF), eosinophils, serum inflammatory cytokines and IgE were recorded. Results The total effective rate was 92.1% in the control group and 92.0% in the intervention group, but the latter was more effective (P <0.05). After treatment, the lung function of both groups improved, but the difference was not statistically significant (P> 0.05). The levels of eosinophils, serum inflammatory cytokines and IgE were decreased in both groups (P <0.01) (P <0.05), the differences were statistically significant. Conclusion Huang Kui capsule can increase the effective rate after treatment, reduce the level of inflammation in the body, improve immunity, but little effect on pulmonary function.