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目的对于阿托伐他汀治疗狼疮肾慢性肾功能不全的疗效进行临床分析。方法选择2008年10月至2010年3月在本院就诊的58例狼疮肾慢性肾功能不全患者,年龄42～75岁,平均(55.8±11.3)岁,其中男42例,女36例,随机分为治疗组(30例)和对照组(28例),两组资料具有可比性。58例患者均予以西医治疗,包括低磷、高维生素、优质低蛋白、蛋白以0.6mg/(kg.d),血压140/90mmHg以上者应用降压药,治疗组在常规治疗的基础上再加用阿托伐他汀10mg/d。结果治疗组治疗前后24h尿蛋白定量明显减少,差异有统计学意义(P<0.01);对照组治疗前后24h尿蛋白定量减少差异有统计学意义(P<0.05)。结论在西医治疗慢性肾脏病的基础上加用阿托伐他汀治疗取得较好疗效。
Objective To evaluate the clinical efficacy of atorvastatin in the treatment of chronic renal failure caused by lupus nephritis. Methods Fifty-eight patients with lupus renal failure, aged from 42 to 75 years, with an average age of 55.8 ± 11.3 years, including 42 males and 36 females, were selected in our hospital from October 2008 to March 2010. Divided into the treatment group (30 cases) and the control group (28 cases), the two groups of data is comparable. 58 patients were treated with Western medicine, including low-phosphorus, high-vitamin, high-quality low protein, protein 0.6mg / (kg.d), blood pressure 140 / 90mmHg or more antihypertensive drugs, the treatment group on the basis of conventional treatment Add atorvastatin 10mg / d. Results The proteinuria of urinary protein in treatment group before and after treatment was significantly lower than that in the control group (P <0.01), and the decrease of urinary protein in control group before and after treatment was statistically significant (P <0.05). Conclusion Western medicine treatment of chronic kidney disease based on the use of atorvastatin treatment achieved good results.