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摘要[背景]空气动力学直径≤2.5μm的颗粒物(PM2.5)在不同程度上与早产(PTB)相关联。[目的]我们将PTB分为四类(妊娠期为20~27、28~31、32~34和35~36周),并估计每类的风险差异(RD)与怀孕期间每周PM2.5暴露每增加1μg/m3之间的关联。[方法]使用来自三个州(宾夕法尼亚州、俄亥俄州和新泽西州)活产证明数据(n=1 940 213;8%PTB)建立了一个单胎妊娠的队列,研究对象在2000—2005年中妊娠期≥20周。用监测器校正的社区多尺度空气质量模拟数据估计每个妊娠周PM2.5暴露的平均值。采用改进的泊松线性回归模型并校正产妇种族/民族、婚姻状况、教育
Abstract BACKGROUND [0002] Particles with an aerodynamic diameter <2.5 [mu] m (PM2.5) are associated to varying degrees with preterm birth (PTB). [Purpose] We classify PTBs into four groups (gestational 20-27, 28-31, 32-34, and 35-36 weeks) and estimate the difference in risk (RD) between each category as well as the weekly PM2.5 Exposure was increased by 1 μg / m3 for each association. [Method] A cohort of singleton pregnancies was established using live birth certificate data from three states (Pennsylvania, Ohio and New Jersey) (n = 1, 940; 213; 8% PTB) from 2000 to 2005 Pregnancy ≥ 20 weeks. The average of PM2.5 exposure per gestation week was estimated using monitor-corrected community multiscale air quality simulation data. Adopt improved Poisson linear regression model and correct maternal race / ethnicity, marital status, education