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作者报告1例50岁男性。白细胞34000/μl,中性61%,嗜碱性3%,碱性磷酸酶5%细胞阳性,分裂细胞100%有Ph~1染色体异常,脾肿大。用马利兰及Zyloric治疗,4年后,白细胞为25900/μl,其中19%为嗜碱性;又1年后,嗜碱性达20%,伴贫血及血小极减少。骨髓活检示Ⅲ度纤维化,用雄激素治疗,同年白细胞上升到107000/μl,嗜碱性占51%,脾大达髂窝,进行脾切除,染色体检查分裂细胞中100%为第8对染色体有三体畸形,碱性磷酸酶阳性细胞为45%,手术之后,嗜碱性细胞达75%,给予强化疗(环磷酰胺及阿糖胞苷)及全身放疗后,进行自身骨髓移植(用低温保存的外周血)。移植后35天,白细胞总数为27400/μl,其中92%为多形核,无嗜碱细胞,病员因CMV感染而
The authors report a 50-year-old male. Leukocyte 34000 / μl, neutral 61%, basophilic 3%, alkaline phosphatase 5% positive cells, split cell 100% Ph ~ 1 chromosomal abnormalities, splenomegaly. After 4 years of treatment with Maryland and Zyloric, 25900 / μl of leukocytes were found, of which 19% were basophilic. After 1 year, basophilicity reached 20% with anemia and minimal hypoproteinemia. Bone marrow biopsy showed grade III fibrosis, and androgen treatment, the same year white blood cells rose to 107000 / l, 51% basophilic, spleen up to the iliac fossa, splenectomy, chromosomal examination of 100% of dividing cells for chromosome 8 With trisomy, 45% of alkaline phosphatase-positive cells, 75% of basophils after surgery, intensive chemotherapy (cyclophosphamide and cytarabine), and systemic radiotherapy, followed by autologous bone marrow transplantation Preserved peripheral blood). 35 days after transplantation, the total number of leukocytes 27400 / μl, of which 92% of polymorphonuclear, no basophils, patients with CMV infection and