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目的:探讨三七总皂苷干预颅脑外伤术后深静脉血栓形成的效果。方法:颅脑外伤术后深静脉血栓形成患者170例根据随机抽签原则分为治疗组与对照组各85例,对照组给予常规治疗,在此基础上治疗组给予三七总皂苷粉剂注射治疗,都治疗7 d。结果:治疗组与对照组的治疗有效率分别为94.1%和83.5%,治疗组的治疗有效率明显高于对照组(P<0.05)。治疗后两组的血清NSE与S-100B含量都明显下降(P<0.05),同时治疗后治疗组的血清NSE与S-100B含量明显低于对照组(P<0.05)。治疗后治疗组的疼痛管理、躯体功能与症状应对评分都明显高于对照组(P<0.05)。治疗后治疗组的躯体疼痛、生理职能、生理功能、社会功能评分都明显高于对照组(P<0.05)。结论:三七总皂苷辅助干预颅脑外伤术后深静脉血栓形成能有效降低血清NSE与S-100B含量,从而提高总体治疗疗效,有利于促进患者的健康。
Objective: To investigate the effect of Panax notoginseng saponins on deep venous thrombosis after craniocerebral trauma. Methods: 170 patients with deep venous thrombosis after craniocerebral trauma were divided into treatment group and control group according to the principle of random sampling. The control group was given routine treatment. On the basis of this, the treatment group was given Panax notoginseng saponin injection, Treatment for 7 days. Results: The effective rates of the treatment group and the control group were 94.1% and 83.5%, respectively. The treatment efficiency in the treatment group was significantly higher than that in the control group (P <0.05). Serum levels of NSE and S-100B in the two groups were significantly decreased after treatment (P <0.05), while serum NSE and S-100B levels in the treatment group were significantly lower than those in the control group after treatment (P <0.05). After treatment, pain management, physical function and symptom coping scores of the treatment group were significantly higher than those of the control group (P <0.05). After treatment, the body pain, physical function, physiological function and social function score of the treatment group were significantly higher than those of the control group (P <0.05). Conclusion: The intervention of Panax Notoginseng Saponins can effectively reduce the content of NSE and S-100B in patients with deep venous thrombosis after craniocerebral trauma, so as to improve the overall curative effect and promote the health of patients.