苯妥英钠(phenytoinsodium,PS)虽是治疗除失神发作外各型癫痫病的首选药物之一,但长期服用后可引起小脑萎缩。苯妥英锌(phenytoinzinc,PZ)的抗癫痫作用及急性和亚急性毒性与PS相近,但大鼠长期口服后对脑重量的影响正好与PS相反,提示PZ长期服用后有可能减轻小脑萎缩。本研究选用 Although phenytoinsodium (PS) is one of the first choice drugs for the treatment of various types of epilepsy except absence seizures, it can cause cerebellar atrophy after long-term administration. The antiepileptic and acute and subacute toxicities of phenytoinzinc (PZ) were similar to those of PS. However, the effects of long-term oral administration of PZ on brain weight were opposite to that of PS, suggesting that the long-term administration of PZ may reduce cerebellar atrophy. Selected for this study