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目的:探讨肾移植术后巨细胞病毒(cytomegalovirus,CMV)感染的诊断、治疗与预防方法。方法:回顾性分析28例肾移植患者临床资料,检测手术前、后血中CMV抗原和CMV抗体及肾脏穿刺标本组织中CMV抗原的表达,并采用静脉注射更昔洛韦进行预防与治疗。结果:11例发生CMV感染,均为无临床症状的CMV感染,均治愈。结论:积极预防、早期治疗肾移植术后CMV感染至关重要,CMV抗原检测和免疫组织化学检测共同应用能够对CMV感染作出早期诊断,更昔洛韦能有效治疗CMV感染。
Objective: To investigate the diagnosis, treatment and prevention of cytomegalovirus (CMV) infection after renal transplantation. Methods: The clinical data of 28 renal transplant recipients were retrospectively analyzed. The expression of CMV antigen and CMV antibody in the blood before and after the operation, and the CMV antigen in the renal puncture specimens were analyzed retrospectively. The patients were treated with intravenous ganciclovir for prevention and treatment. Results: Eleven patients had CMV infection, all of which were CMV infection without clinical symptoms and were cured. CONCLUSION: Active prevention and early treatment of CMV infection after renal transplantation is very important. Combined detection of CMV antigen and immunohistochemistry can make early diagnosis of CMV infection. Ganciclovir can effectively treat CMV infection.