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目的研究大蒜多糖对小鼠胃溃疡的保护作用。方法将昆明种小鼠随机分为正常对照组、模型对照组、阳性对照组、大蒜多糖低剂量组、大蒜多糖中剂量、大蒜多糖高剂量组6组;采用无水乙醇灌胃诱发小鼠急性胃溃疡模型,测定各组胃溃疡面积,计算胃溃疡指数和溃疡抑制率;取出小鼠胃黏膜组织,石蜡包埋作HE染色,测定血清中丙二醛(MDA)的含量和超氧化物歧化酶(SOD)的活性,观察胃黏膜病理改变及损伤程度。结果大蒜多糖各剂量组及雷尼替丁组溃疡指数较模型组均有显著减小(P<0.01),大蒜多糖低剂量组的溃疡抑制率最高(P<0.01)。与正常组比较,模型组小鼠组织MDA含量显著升高,SOD活性显著降低(P<0.01)。与模型组比较,大蒜多糖各剂量组及雷尼替丁组组织中MDA的含量降低,SOD的活性升高,差异均有统计学意义(P<0.01)。结论大蒜多糖对无水乙醇致小鼠胃溃疡具有一定的保护作用。
Objective To study the protective effect of garlic polysaccharide on gastric ulcer in mice. Methods Kunming mice were randomly divided into 6 groups: normal control group, model control group, positive control group, low dosage of garlic polysaccharide, medium dosage of garlic polysaccharide and high dosage of garlic polysaccharide. Acute ethanol injection Gastric ulcer model was established. Gastric ulcer area was measured in each group. Gastric ulcer index and ulcer inhibition rate were calculated. Gastric mucosa tissues of mice were taken out and paraffin-embedded for HE staining to measure the content of malondialdehyde (MDA) and superoxide dismutase Enzyme (SOD) activity, observe gastric mucosal pathological changes and the degree of injury. Results Compared with the model group, the ulcer index of garlic polysaccharide and ranitidine groups were significantly decreased (P <0.01). The inhibition rate of ulcer with garlic polysaccharide low dose group was the highest (P <0.01). Compared with the normal group, the content of MDA in the model group increased significantly and the SOD activity decreased significantly (P <0.01). Compared with the model group, the content of MDA and the activity of SOD in garlic polysaccharide and ranitidine groups were significantly decreased (P <0.01). Conclusion Garlic polysaccharides have a protective effect on gastric ulcer caused by ethanol in mice.