骨髓通常被认为是初级淋巴器官,为干细胞提供向淋巴系或髓系分化所必需的独特微环境,即龛位。早期B细胞的发育是在骨髓中进行,并经历了一系列的分化阶段,如前祖B细胞、祖B细胞、前B细胞。随后,未成熟B细胞离开骨髓迁移到脾 Bone marrow, commonly referred to as primary lymphoid organs, provides the stem cells with a unique niche, or niche, necessary for differentiation into the lymphoid or myeloid lineage. The development of early B cells is performed in the bone marrow and undergoes a series of differentiation stages, such as progenitor B cells, progenitor B cells, and pre-B cells. Subsequently, immature B cells migrate from the bone marrow to the spleen