论文部分内容阅读
目的：考察注射用盐酸氨溴索、更昔洛韦钠与8种溶媒配伍稳定性，并将二者配伍观察溶液稳定性，为临床合理用药提供参考。方法观察2种药物在0.9%氯化钠、5%葡萄糖、10%葡萄糖、复方氯化钠、葡萄糖氯化钠、木糖醇氯化钠、小儿电解质补给注射液和灭菌注射用水8种溶媒中以临床常用浓度溶解后0、0.5、1、2、4、6、8 h的pH值，观察2种溶液等体积混合和盐酸氨溴索以入壶给药加入到更昔洛韦钠的溶液中颜色、透明度的变化。结果8种溶媒和盐酸氨溴索溶液在8 h内pH值的RSD均在0~2.30%，更昔洛韦钠溶液的pH值的RSD在0~1.2%。2种药物等体积混合后均可见白色颗粒物。盐酸氨溴索入壶给药后立即产生白色沉淀。三组溶液在0~8 h的平均pH值分别进行检验，≤0.05，无显著性差异。结论三组溶液pH值在8 h内稳定，2种药物在8种溶媒中溶解后两两混合存在配伍禁忌，临床应用应注意。“,”Objective To investigated the compatible stability of Ambroxol hydrochloride injection and Ganciclovir sodium injection in 8 solutions and to improve the rational use in the clinic. Methods The pH value of the compatible stability of the 2 injections in 8 solutions were determined within 0-8 h, respectively. The changes of color and transparency were observed after the 2 injections were mixed equal y at room temperature. Results The range of the relative standard deviation (RSD) of the pH value of the 8 solutions and the Ambroxol hydrochloride were between 0~2.3%in 8 h, respectively. The ganciclovir sodium was 0~1.2%. The white precipitate was observed when the ambroxol hydrochloride injection was mixed with ganciclovir sodium injection by the way of going into pot. The P value of the t test for the 3 groups were al less than 0.05. Conclusion The pH value of the 3 groups were al stable in 8 h. Ambroxol hydrochloride injection was shown to be incompatible with ganciclovir sodium injection in the 8 solutions.